Isotretinoin, also known as Accutane , is a retinoid that treats severe cystic acne, ichthyosis and some cancers. It has many side effects, including birth defects, liver failure and psychiatric problems, and requires strict controls and monitoring. Accutane (isotretinoin) is a form of vitamin A and is used to treat severe nodular acne. Includes Accutane side effects, interactions and indications. What Is Isotretinoin ( Accutane )? How Does Isotretinoin Work? Side Effects Pregnancy Suicide and Depression Take with a High-fat Meal Do Not Buy Isotretinoin on the Internet! Presentation of Bias What Is Isotretinoin ( Accutane )? Isotretinoin, originally known for its brand name Accutane ®, or Roaccutane ® in parts of the world, was discovered in 1979 when it was first given to patients with severe acne, most of whom reacted with dramatic and permanent clearing of their acne symptoms. It is ... Isotretinoin is a powerful medication that can clear severe cystic acne, but it also has serious risks and limitations. Learn how it works, what to expect, and who it's not for.