Advanced cardiac life support (ACLS) refers to interventions for urgent treatment of cardiac arrest and other life-threatening emergencies, as well as the knowledge and skills to deploy those interventions. Advanced Cardiac Life Support (ACLS) The American Heart Association’s Advanced Cardiac Life Support Course highlights the importance of high-performance team dynamics and communication, systems of care, recognition and intervention of cardiopulmonary arrest, immediate post-cardiac arrest, acute dysrhythmia, stroke, and acute coronary syndromes (ACS). Learn more about what is ACLS and why it is important for healthcare providers. Enroll in our AHA-certified online, onsite, or classroom ACLS Course. Advanced Cardiac Life Support (ACLS) is an essential aspect of emergency medical care aimed at improving the survival rates of patients facing life-threatening conditions such as cardiac arrest, heart attack, or stroke.