Apocalypse definition: a prophecy or revelation , especially regarding a final cataclysmic battle between good and evil.. See examples of APOCALYPSE used in a sentence. Definition of apocalypse noun from the Oxford Advanced Learner's Dictionary. [singular, uncountable] the destruction of the world. We're all waiting for the zombie apocalypse . Civilization is on the brink of apocalypse . [singular] a situation causing very serious damage and destruction. apocalypse (plural apocalypses) A revealing, especially a prophecy of, or the unfolding of, supernatural events. [from 14th c.] synonym Synonym: revelation Apocalypse is a word that means "the end of the world" — or something so destructive it seems like the world has ended, like the event of a major earthquake.