Buerger’s Disease affects blood flow to the limbs, often caused by smoking. Learn about its symptoms, causes, diagnosis, and how to manage and prevent this serious vascular condition. Buerger’s disease is a disease that can cause inflammation of blood vessels in the hands and feet. Using tobacco increases your risk of developing it and the likelihood of serious complications. Buerger’s disease is a serious condition that affects blood vessels in the arms and legs, causing pain, tissue damage, and sometimes amputation. It is strongly linked to tobacco use and has no cure, only prevention by quitting smoking. Buerger's disease or thromboangitis is an inflammatory non atherosclerotic, segmental inflammatory disease affects small and medium arteries and veins of the upper and lower limbs and more common in tobacco use patients, more common in men than women< 45 years but in last decades it is prevalence between women increase may be due to increase in number of women tobacco use. There is a strong association between heavy tobacco use and the development of Buerger's disease[1].