Chickenpox causes itching, blisters, and a rash due to a viral infection from the varicella virus. Learn how it’s treated and if you should quarantine. Most people who have had chickenpox or have gotten the vaccine are immune to chickenpox . If you've been vaccinated and still get chickenpox , symptoms are often milder. You may have fewer blisters and mild or no fever. A few people can get chickenpox more than once, but this is rare. Debunk the Myths and separate fact from fiction about Chicken Pox . Read and know about the causes, symptoms & treatment. The most common late complication of chickenpox is shingles (herpes zoster), caused by reactivation of the varicella zoster virus decades after the initial, often childhood, chickenpox infection.