One of the primary differences between DNA and RNA is that DNA is double-stranded while RNA is single-stranded. Table of Contents Difference DNA Structure Types RNA RNA Types Proteins Frequently Asked Questions Read on to explore the DNA and RNA differences in detail. Differences between DNA and RNA. DNA vs RNA. Deoxyribonucleic Acid. Ribonucleic Acid. DNA is found in the nucleus, with a small amount of DNA. Explore the key similarities and differences between DNA and RNA, unraveling their roles in genetics and cellular functions. Enhance your understanding! DNA is the master blueprint for life and constitutes the genetic material in all free-living organisms. RNA uses DNA to code for the structure of proteins synthesized in cells, and it is also the genetic material of certain viruses. There are several chemical differences between the two structures.