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HOLISTIC meaning : 1. dealing with or treating the whole of something or someone and not just a part: 2. dealing with…. Learn more. Holistic means relating to or concerned with complete systems rather than with individual parts. Learn how holistic medicine, education, and approach can improve our health and well-being. Holistic definition : incorporating the concept of holism, or the idea that the whole is more than merely the sum of its parts, in theory or practice.. See examples of HOLISTIC used in a sentence. Holistic medicine tries to treat the "whole person" rather than focusing too narrowly on single symptoms. It emphasizes the connections between the mind and the body, avoids the overuse of drugs, and has borrowed such practices from Eastern traditions as acupuncture and yoga.