The HTT gene provides instructions for making a protein called huntingtin. Although the exact function of this protein is unknown, it appears to play an important role in nerve cells (neurons) in the brain and is essential for normal development before birth. Mutation in huntingtin leads to Huntington’s disease. In this issue of Neuron, Saudou and Humbert highlight wild-type huntingtin-regulated molecular and cellular mechanisms that could be dysfunctional in Huntington‘s disease and the impact on the specificity and severity of this disorder. The Htt gene, also known as the huntingtin gene, plays a crucial role in the regulation of various cellular processes. This gene encodes the huntingtin protein, which is involved in important functions such as vesicle trafficking, gene transcription, and protein degradation. Mutations in the Htt gene can lead to the development of Huntington’s disease, a debilitating neurodegenerative disorder. One of the key features of the Htt gene is its ability to undergo alternative splicing, which ... HTTrack is a free (GPL, libre/free software) and easy-to-use offline browser utility. It allows you to download a World Wide Web site from the Internet to a local directory, building recursively all directories, getting HTML, images, and other files from the server to your computer. HTTrack arranges the original site's relative link-structure. Simply open a page of the 'mirrored' website in your browser, and you can browse the site from link to link, as if you were viewing it online. HTTrack ...
