The meaning of NEPHEW is a son of one's brother, sister, brother-in-law, or sister-in-law. Learn the meaning and usage of the word nephew , the son of your brother or sister or of your spouse's sibling. See pictures, synonyms and compare with niece. NEPHEW definition: 1. a son of your sister or brother, or a son of the sister or brother of your husband or wife 2. a…. Learn more. Learn the etymology, pronunciation, and meaning of the word nephew , as well as its synonyms, derived terms, and translations. A nephew is a son of one's sibling, cousin, or child.