A plasmid is a small, circular piece of DNA that is different than the chromosomal DNA and replicates independently of it. Learn about the different types of plasmids, such as F-plasmids, R-plasmids, and Col-plasmids, and their functions and applications in biology. Plasmid, in microbiology, an extrachromosomal genetic element that occurs in many bacterial strains. Plasmids are circular deoxyribonucleic acid (DNA) molecules that replicate independently of the bacterial chromosome. They are not essential for the bacterium but may confer a selective advantage. Learn about plasmids, small circular DNA molecules that carry genes and can transfer between bacteria. Discover the different types of plasmids, such as F, R, Col, and Virulence, and how they are used in cloning and biotechnology. Plasmid are small, extra-chromosomal, circular, super-coiled, double stranded DNA molecule present in mostly all species of bacteria. A plasmid is a DNA molecule, other than the bacterial chromosomes that has the ability of replication and transmission independently.