Prochlorperazine suppositories and tablets are used to control severe nausea and vomiting. Prochlorperazine tablets are also used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Prochlorperazine is a prescription drug used to treat anxiety or schizophrenia. It can cause serious side effects such as muscle movements, jaundice, or lupus-like symptoms. It interacts with many other drugs and should be used with caution. Prochlorperazine is a phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting.