This comprehensive review covers the historical background, physiology, application in type 2 diabetes, novel uses, cardiovascular benefits, side effects and contraindications of sodium-glucose cotransporter-2 ( SGLT2) inhibitors . SGLT2 inhibitors ... SGLT2 inhibitors are a class of drugs that lower blood sugar by blocking glucose reabsorption in the kidney. They have cardiovascular benefits and may cause genital infections, ketoacidosis, bone fractures, and amputation. SGLT2 Inhibitor , Biological Activity Validated. High Purty. NMR/MS/HPLC Validated. Professional Technical Support. SGLT2 inhibitors are a type of medicine you might take to lower your blood sugar when you have type 2 diabetes. They increase the amount of blood sugar (or glucose) you get rid of when you pee.