Stuff is one of those words you use in all kinds of contexts, or for all kinds of stuff. When you throw a bunch of stuff into a bag, you could be referring to any arrangement of things. When you talk about someone's possessions, informally, you're talking about his stuff. stuff meaning, definition, what is stuff: used when you are talking about things s...: Learn more. stuff (usually uncountable, plural stuffs) (informal) Miscellaneous items or objects; (with possessive) personal effects. quotations Define stuff. stuff synonyms, stuff pronunciation, stuff translation, English dictionary definition of stuff. n. 1. The material out of which something is made or formed; substance. 2. The essential substance or elements; essence: "We are such stuff / As dreams are...