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Description Adapalene is used to treat acne. It works partly by keeping skin pores clear. Adapalene is available only with your doctor's prescription. How to Use Adapalene Dr. King recommends applying a thin layer of the gel (about a pea-sized amount) onto clean, dry skin. Because adapalene works to both treat and prevent acne, it should be applied across the entire face, not as a spot treatment. As far as timing is concerned, adapalene, just like any other retinol, should be applied in the ... Adaferin Gel is a prescription medicine used to treat acne on the face, chest, or back. It contains adapalene , a vitamin A derivative from the retinoid family. Adapalene works by reducing inflammation, preventing clogged pores, and increasing the turnover of skin cells. This helps clear blackheads, whiteheads, and pimples while also preventing new breakouts. Since only very small amounts are absorbed into the body, its effects are focused mainly on the skin’s surface. Adaferin Gel is ... Adapalene is a third-generation topical retinoid with anti-comedogenic, comedolytic, and anti-inflammatory properties used to treat acne vulgaris in adolescents and adults.