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Calcium channel blockers differ in their duration of action, the process by which they are eliminated from the body, and, most importantly, in their ability to affect heart rate and contraction. Some calcium channel blockers (for example, amlodipine [Norvasc]) have very little effect on heart rate and contraction so they are safer to use in individuals who have heart failure or bradycardia (a slow heart rate). Verapamil (Calan, Isoptin) and diltiazem (Cardizem) have the greatest effects on ... Calcium channel blockers (CCBs) are prescribed to treat high blood pressure, chest pain, and irregular heartbeats by reducing calcium flow to the heart and arteries. Common side effects of CCBs ... Learn about calcium channel blockers , a group of medications that disrupt the movement of calcium through calcium channels. Find out their uses, classes, side effects, and examples.