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People with Down syndrome have an extra chromosome that impacts their looks and their ability to think, learn, and reason. Discover the type, causes, and kinds of effects it can have. The symptoms of Down syndrome vary from person to person, and people with Down syndrome may have different problems at different times of their lives. Key points Down syndrome is a genetic condition where a person is born with an extra chromosome. This can affect how their brain and body develop. People diagnosed with Down syndrome can lead healthy lives with supportive care. Each person with Down syndrome is an individual. Problems with intellect and development are usually mild to moderate. Some people are healthy while others have serious health issues such as heart problems that are present at birth. Children and adults with Down syndrome have distinct face and body features.