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The actions of estrogen are mediated by the estrogen receptor (ER), a dimeric nuclear protein that binds to DNA and controls gene expression. Like other steroid hormones , estrogen enters passively into the cell where it binds to and activates the estrogen receptor. Estrogen is a hormone that both males and females produce . It plays a key role in the female reproductive system. Learn about sources of estrogen and its functions. Estrogens Estrogen is a generic term that refers to molecules that activate the endogenous estrogen receptors. The primary endogenous estrogens in humans, in order of their potency at the genomic estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ), are 17β-estradiol (hereinafter referred to as estradiol or E2), estrone, and estriol (Kuiper et al., 1997). These natural estrogens are derived from the parent cholesterol molecule through a series of enzymatic reactions that result ... Estrogen , a steroid, is a category of sex hormone . There are three major endogenous estrogens that have estrogenic hormonal activity: estrone, estradiol, and estriol. They are formed from androgen precursors, that are secreted chiefly by the ovaries, placenta, adipose tissue, and testes. They stimulate the development and maintenance of female secondary sex characteristics, exert systemic effects such as the growth and maturation of long bone s, promote estrus in many female mammals, and are ...
