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GRBS stands for General Random Blood Sugar, a test to measure glucose amount in the blood. Learn how to do the test, what the readings mean, and when to do it for diabetes or prediabetes. The key difference between FBS RBS and GRBS is that FBS (fasting blood sugar) is a test carried out after a certain time period of fasting, usually overnight, while RBS (random blood sugar) and GRBS (general random blood sugar) are tests carried out at any time of the day without fasting. The body requires glucose for energy. We would like to show you a description here but the site won’t allow us. The random blood sugar or RBS test is prescribed mainly to check the level of sugar or glucose in the blood for diabetes diagnosis.