In this sequel to "The Silence of the Lambs," serial killer Hannibal Lecter's only surviving victim tries to draw him out of hiding. Watch trailers & learn more. This drama series focuses on the early years of the relationship between FBI criminal profiler Will Graham and homicidal cannibal Dr. Hannibal Lecter. Watch trailers & learn more. Hannibal is a 2001 American horror film directed by Ridley Scott from a screenplay by David Mamet and Steven Zaillian. Based on the novel of the same name by Thomas Harris, it is a sequel to the 1991 film The Silence of the Lambs. Its plot follows disgraced FBI special agent Clarice Starling as she attempts to apprehend the cannibalistic serial killer Hannibal Lecter before his surviving victim, Mason Verger, captures him. Anthony Hopkins reprises his role as Lecter, while Julianne Moore ... Both a gift and a curse, Graham has the extraordinary ability to think like his prey—he sees what they see, feels what they feel. But while Graham is pursuing an especially troubling, cannibalistic murderer, Special Agent Jack Crawford teams him with a highly respected psychiatrist – a man with a taste for the criminal minded – Dr. Hannibal Lecter.