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Think a disease and an illness are the same thing? An internal medicine physician explains the difference. ILLNESS meaning: 1. a disease of the body or mind: 2. the state of being ill: 3. a disease of the body or mind: . Learn more. Learn how disease and illness differ in definition, cause, symptom, treatment, and impact. Disease is a specific medical condition, while illness is a broader state of poor health or feeling unwell. Learn the meaning, pronunciation and usage of the word illness, a noun for the state of being physically or mentally ill. Find out the difference between illness and disease, and see related words and collocations.