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Insulin Resistance: Causes and Solutions In recent years, insulin resistance has garnered significant attention in the medical community due to its critical role in the pathogenesis of type 2 diabetes and other metabolic disorders. As a condition characterized by the body's diminished ability to respond to insulin, insulin resistance represents a pivotal concern for both healthcare professionals and individuals striving for optimal health. This article delves into the causes, symptoms ... What is insulin resistance? Insulin resistance happens when cells in your muscles, fat and liver don’t respond to insulin as they should. This is also known as impaired insulin sensitivity. Insulin is essential for life and regulating blood glucose (sugar) levels. Insulin helps the body use glucose to produce energy. Insulin resistance occurs when excess sugar circulates in the body. Over time, it can lead to diabetes. INSULIN RESISTANCE definition: 1. a condition in which the body's muscles and other tissues do not accept the insulin that they…. Learn more.