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Kidney disease is often called a silent killer because its symptoms can be mild or go unnoticed until the condition becomes serious. That’s why it’s crucial to recognize the early symptoms of kidney disease and seek medical help in time. If you experience swelling, fatigue, changes in urination, or pain in your kidney area, don’t wait. Chronic kidney disease (CKD) is a serious medical condition in which the kidneys slowly lose their ability to work properly, either due to disease , injury, alcohol abuse, obesity, or diabetes. In ... Kidney disease affects more than 35 million Americans. 90% don't know they have it. Learn the symptoms , risk factors, and how to get tested for early detection. Kidney disease symptoms can include fatigue, nausea, foamy urine, and ammonia-smelling breath and progress to renal failure, cardiac failure, and death.