Lamotrigine is used alone or with other medications to prevent or control seizures (epilepsy).Learn about side effects, dosages, drug interactions, and more. Lamotrigine reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI). Lamotrigine can cause serious rashes requiring hospitalization and discontinuation of treatment. The incidence of these rashes, which have included Stevens-Johnson syndrome, is approximately 0.3% to 0.8% in pediatric patients (aged 2 to 17 years) and 0.08% to 0.3% in adults receiving lamotrigine . Lamictal is a generic drug used to treat certain types of seizures and bipolar disorder. Learn about its side effects, dosage, interactions, warnings, and how to avoid serious skin rashes.