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You lose your temper or lose a round at poker, but you don't have ' lose change' ( loose change). There's a loose screw or you need to loose a knot, but you don't loose your mind. Read on for some more idioms with the correct usage of lose and loose . LOOSE definition: 1. not firmly held or fastened in place: 2. Loose hair is not tied back: 3. Loose things are not…. Learn more. Learn the various meanings and uses of the word loose , such as not firmly held, not exact, or willing to have casual sex. See synonyms, examples, pronunciation, and related phrases. The meaning of LOSE is to miss from one's possession or from a customary or supposed place. How to use lose in a sentence.