Learn how to use Neosporin properly, what it can be used for, what ingredients it contains, and more. Discover Neosporin® Original Triple Antibiotic Ointment . Made with polymyxin, bacitracin, and neomycin, this first aid ointment helps protect minor wounds from infection. Overview: Topical triple antibiotic is applied to your skin to reduce the risk of infection from minor wounds or injuries. Topical triple antibiotic should only be used on your skin after... Neosporin Ointment is a combination medicine which works by stopping the growth of infection-causing bacteria on your skin. It prevents the synthesis of essential proteins necessary for the survival of bacteria. Neosporin is a combination of antibiotics that prevent infections in minor cuts, scrapes, or burns on your skin. Learn how to use it, what side effects to watch out for, and what interactions to avoid with other drugs.