Nucleosides are glycosylamines composed of a nucleobase and a five-carbon sugar, while nucleotides have a phosphate group. Learn about the structure, synthesis, and use of nucleosides in medicine, technology, and prebiotic chemistry. Nucleotides are comprised of three distinguishing elements: (1) a nitrogenous (nitrogen-containing) base, (2) a pentose, and (3) a phosphate. A nucleoside is the molecule without the phosphate group. The nitrogenous bases are derived from pyrimidine and purine, two parent molecules. The common nucleotides’ bases and pentoses are heterocyclic compounds. The base of a nucleotide is covalently attached to the 1′ carbon of the pentose via an N-B-glycosyl link (at N-1 for pyrimidines and N-9 ... How do nucleotides and nucleosides differ? Nucleoside = Nitrogenous base + Sugar Adenosine, Guanosine, Thymidine, Cytidine, and Uridine are all names for nucleosides. Nucleotide = Nucleoside + Phosphate Nucleotides are named as Adenylic acid, Guanylic acid, Thymidylic acid, Cytidylic acid and Uridylic acid. A nucleoside is a structural subunit of nucleic acids, the heredity-controlling components of all living cells, that consists of a sugar molecule linked to a nitrogen-containing organic ring compound.

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