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Polymyxin B is an effective antibiotic medicine to treat infections of the urinary tract, eye, ear, skin, bloodstream, and layers covering the brain (meninges) caused by sensitive gram-negative bacteria. Polymyxin B (Polymyxin B Sulfate) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Polymyxins comprise a class of antibiotics targeting gram-negative bacterial infections. Polymyxin B and Polymyxin E (colistin) are the two drugs within this antibiotic class used primarily in clinical practice. Polymyxin B is primarily used to manage severe infections caused by gram-negative bacteria, especially when other antibiotics are ineffective. It belongs to a group of medications known as cyclic polypeptides.