However, many people still keep a close eye on any positive sign that may indicate a successful embryo transfer . And while you may experience some or none of these symptoms, it’s important... Important Note: Other than these positive signs after embryo transfer , it’s also important to fully confirm your pregnancy. The only way to confirm pregnancy is through a blood test (beta hCG) about 10-14 days after the transfer . The most common positive signs after embryo transfer that may indicate a successful pregnancy include missed periods, cramping, spotting or mild implantation bleeding three to seven days after implantation, vaginal discharge, breast tenderness, and tiredness. Some patients may start to experience symptoms during the two weeks after the embryo transfer . Others may have no symptoms or experience these signs differently, which is normal and doesn’t mean the treatment was unsuccessful.