The meaning of PURSUE is to follow in order to overtake, catch, kill, or defeat. How to use pursue in a sentence. Synonym Discussion of Pursue . Learn the meaning of pursue as a verb, with different senses and usage examples. Find out how to pronounce pursue , its synonyms, and related words. PURSUING definition : 1. present participle of pursue 2. to follow someone or something, usually to try to catch him…. Learn more. Master the word " PURSUE " in English: definitions, translations, synonyms, pronunciations, examples, and grammar insights - all in one complete resource.