Rhabdomyolysis is the breakdown of muscle cells that can cause serious complications such as kidney failure and multi-organ failure. Learn about the causes, risk factors, investigations, management and prevention of this condition from BMJ Best Practice. Rhabdomyolysis is a serious condition that occurs when muscle tissue breaks down and releases toxins into the blood. Learn about the common causes, risk factors, diagnosis, and treatment options for this potentially life-threatening disorder. Rhabdomyolysis is a condition in which damaged skeletal muscle breaks down rapidly, often due to high intensity exercise or crush injury. It can cause kidney failure, electrolyte disturbances, and other complications. Learn about the causes, symptoms, diagnosis, and treatment of rhabdomyolysis . The main rhabdomyolysis (rhabdo) symptoms are muscle pain, dark urine, and feeling weak or tired. Seek medical attention immediately if you experience any symptoms. Rhabdo symptoms can mimic other conditions like heat cramps and dehydration. A healthcare provider can perform a specific blood test to determine if you have rhabdo.