Senescence: Is the gradual deterioration of

Senescence is the gradual deterioration of functional characteristics in living organisms with age. Learn about the hallmarks, evolutionary and mechanistic theories of senescence, and the variation among species and organisms. Senescence is the process by which cells stop dividing and enter a state of permanent growth arrest without undergoing cell death. Senescence cells get old and weaken, causing a decline in tissue function and decay. Senescence in plants is a programmed death of leaves as part of developmental cycles. In animals, senescent cells contribute to aging and age-related diseases. Senescence can be induced by unrepaired DNA damage or other cellular stresses. It plays a role in normal development ... In this review, we focus on senescence-associated pathways and therapeutics understanding cellular senescence as a cascade that leads to aging, while discussing the recent details on the molecular pathways involved in regulating senescence and the benefits of therapeutic strategies against accumulated senescent cells and their secretions. Senescence The natural process of aging in plants is senescence. It involves all the changes occurring in plants causing the death of tissues, cells and the entire plant body. This process takes place in various ways which affects the entire plant or a part of a plant. Senescence takes place in flowers, leaves, stems, fruits and roots. However, commonly, it takes place at different intervals in different organs. In several perennial herbs such as alfalfa, the complete part over the ground ...