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Mucus vs. Phlegm vs. Sputum Mucus , phlegm , and sputum are terms often used in discussions about respiratory health, but they have distinct meanings and implications for medical diagnosis and treatment. Understanding these differences is essential for both healthcare professionals and patients in identifying and managing respiratory conditions. Mucus Mucus is a viscous, slippery substance produced by the mucous membranes throughout the body, including the lungs, throat, mouth, nose, sinuses ... Mucus is a clear, slippery, gel-like substance that’s part of your immune system. It lines your mucous membranes and helps trap and destroy or clear out germs and harmful particles. It’s also called phlegm, snot or sputum . Sputum is not saliva but the thick mucus (sometimes called phlegm) which is coughed up from the lungs. The body produces mucus to keep the thin, delicate tissues of the respiratory tract moist so that small particles of foreign matter that may pose a threat can be trapped and forced out. SPUTUM definition : 1. liquid from the passages in your body that go to the lungs 2. liquid from the passages in your…. Learn more.