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Systolic vs. diastolic blood pressure: How do they differ? Diastole and systole refer to when the heart muscles relax and contract. The balance between diastolic and systolic pressure determines... The cardiac cycle events can be split into diastole and systole. The diastole indicates ventricular filling, while the systole indicates ventricular ejection or contraction. Though with varying pressures, the systole and diastole occur in both the right and left heart. Diastole represents ventricular filling, and systole represents ventricular contraction/ejection. Systole and diastole occur in both the right and left heart, though with very different pressures (see hemodynamics below). Systolic pressure is the force of blood against artery walls when the heart contracts, while diastolic pressure reflects the force when the heart relaxes and refills.