The urea cycle is a crucial metabolic pathway responsible for eliminating excess nitrogen from the body. First Reaction: Entering the Urea Cycle . Second Reaction - Urea Cycle in Mitochondria. The urea cycle (also known as the ornithine cycle) is a cycle of biochemical reactions that produces urea (NH 2) 2 CO from ammonia (NH 3 ). Animals that use this cycle, mainly amphibians and mammals, are called ureotelic. Urea is formed, enters the bloodstream, is filtered by the kidneys, and is eventually excreted in the urine. The biochemical part of excretion is urea synthesis using the urea cycle , also known as the Ornithine Cycle. It is also known as the Kreb-Henseleit cycle and occurs in the liver. The urea cycle is the body’s way of converting toxic ammonia into urea. Ammonia originates from protein catabolism whether that is secondary to a high-protein diet, deaminations, or during the period of prolonged starvation.
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