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The amount of time Sildenafil takes to work varies from person to person, but it normally takes between half an hour and one hour. However, Sildenafil may take longer to start working if you take it with a heavy meal. Its effect may last for about 3-4 hours. This study demonstrates that, in the majority of these patients with ED, sildenafil remains clinically active 12 hours after administration. Larger studies may be necessary to confirm and clarify the therapeutic window of sildenafil. Sildenafil oral tablet is a prescription medication used to treat erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). How Long Does It Take for Sildenafil to Work? Typically, it takes half an hour to one hour for Sildenafil to start working, so you should allow for that suggested timeframe before engaging in sexual intercourse. It may be reassuring however, that after you take it, it can last for up to four hours in your system.
